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Article

Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in Mice.

International journal of molecular sciences - 30 Mar 2021

Alessio Nicola, Belardo Carmela, Trotta Maria Consiglia, Paino Salvatore, Boccella Serena, Gargano Francesca, Pieretti Gorizio, Ricciardi Flavia, Marabese Ida, Luongo Livio, Galderisi Umberto, D'Amico Michele, Maione Sabatino, Guida Francesca

Abstract excerpt

The bioactive form of vitamin D, 1,25-dihydroxyvitamin D (1,25D3), exerts immunomodulatory actions resulting in neuroprotective effects potentially useful against neurodegenerative and autoimmune diseases. In fact, vitamin D deficiency status has been correlated with painful manifestations associated with different pathological conditions. In this study, we have investigated the effects of vitamin D deficiency on...

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Identifiers

PMID: 33808491
DOI: 10.3390/ijms22073604
PMCID: PMC8036382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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