Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity.

Neuroscience - 4 May 2017

Gong Xingrui, Chen Yongmei, Fu Bao, Jiang Jing, Zhang Mazhong

Abstract excerpt

Neuropathic pain is absent in infants and emergent years after injury. Adult spinal cord microglia play a key role in initiating neuropathic pain, and modulation of microglia is a potential target for treating neuropathic pain. In this study, we evaluated the role of microglia after infant peripheral nerve injury and the effect of exercise on the delayed-onset neuropathic pain. Rat pups received spared nerve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hyperalgesia
Share to Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuralgia

Share to Pain Threshold

Share to Phenotype

Share to Physical Conditioning, Animal

Share to Rats, Wistar

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 28254586
DOI: 10.1016/j.neuroscience.2017.02.051

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infant nerve injury induces delayed microglial polarization to the M1 phenotype, and exercise reduces delayed neuropathic pain by modulating microglial activity.PMID 28254586Read ↗

Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia.Semantic proximity Read ↗

Physiological roles of embryonic microglia and their perturbation by maternal inflammationSemantic proximity Read ↗

Reduced inflammatory phenotype in microglia derived from neonatal rat spinal cord versus brain.Semantic proximity Read ↗

DUSP1 Promotes Microglial Polarization toward M2 Phenotype in the Medial Prefrontal Cortex of Neuropathic Pain Rats via Inhibition of MAPK Pathway.Semantic proximity Read ↗

Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity.Semantic proximity Read ↗

P2X4R+ microglia drive neuropathic pain.Semantic proximity Read ↗

Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex.Semantic proximity Read ↗

Activation of Neuroprotective Microglia and Astrocytes at the Lesion Site and in the Adjacent Segments Is Crucial for Spontaneous Locomotor Recovery after Spinal Cord Injury.Semantic proximity Read ↗

IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.Semantic proximity Read ↗

Overview of neurodevelopment and pain research, possible treatment targets.Semantic proximity Read ↗

Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behaviorSemantic proximity Read ↗

Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.