Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation.

Molecular pain - 1 Jan 2025

Liu Lin, Li Dan-Yang, Zhang Long-Qing, Gao Shao-Jie, Song Fan-He, Wu Jia-Yi, Zhou Ya-Qun, Liu Dai-Qiang, Mei Wei

Abstract excerpt

BACKGROUND: Cancer-induced bone pain (CIBP) is a debilitating complication with few effective treatments. Microglial activation contributes to the progression of CIBP. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor, could inhibit microglial activation. Its effect on CIBP remains unclear. This study aims to investigate the role of 2-DG in CIBP mice and underlying mechanisms. METHODS: In this research, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Deoxyglucose

Share to Inflammation

Share to Microglia

Share to Neuroinflammatory Diseases

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 40444883
DOI: 10.1177/17448069251348778
PMCID: PMC12171252

Genes

TNF
CD86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation.PMID 40444883Read ↗

Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype.Semantic proximity Read ↗

P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models.Semantic proximity Read ↗

Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.Semantic proximity Read ↗

Down-regulation of NOX4 expression in dorsal root ganglion of spinal cord could alleviate cancer induced bone pain in rats by reducing oxidative stress responseSemantic proximity Read ↗

Contribution of TREM2 Signaling to the Development of Painful Diabetic Neuropathy by Mediating Microglial Polarization in MiceSemantic proximity Read ↗

Calcitonin Gene-related Peptide Attenuated Discogenic Low Back Pain by Inhibiting Microglia Activation Through the NLRP3/caspase-1 Signaling PathwaySemantic proximity Read ↗

DUSP1 Promotes Microglial Polarization toward M2 Phenotype in the Medial Prefrontal Cortex of Neuropathic Pain Rats via Inhibition of MAPK Pathway.Semantic proximity Read ↗

Microglial TLR4 Mediates Post-UTI Chronic Pelvic PainSemantic proximity Read ↗

Targeting the PNN–Microglia Axis: Evidence for Exercise-Induced Central and Peripheral Anti-Inflammatory Reprogramming in OsteoarthritisSemantic proximity Read ↗

TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysisSemantic proximity Read ↗

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt‐dependent waySemantic proximity Read ↗

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.