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Article

Insights into the Role of the Microbiota and of Short-Chain Fatty Acids in Rubinstein-Taybi Syndrome.

International journal of molecular sciences - 31 Mar 2021

Di Fede Elisabetta, Ottaviano Emerenziana, Grazioli Paolo, Ceccarani Camilla, Galeone Antonio, Parodi Chiara, Colombo Elisa Adele, Bassanini Giulia, Fazio Grazia, Severgnini Marco, Milani Donatella, Verduci Elvira, Vaccari Thomas, Massa Valentina, Borghi Elisa, Gervasini Cristina

Abstract excerpt

The short-chain fatty acid butyrate, produced by the gut microbiota, acts as a potent histone deacetylase (HDAC) inhibitor. We assessed possible ameliorative effects of butyrate, relative to other HDAC inhibitors, in in vitro and in vivo models of Rubinstein-Taybi syndrome (RSTS), a severe neurodevelopmental disorder caused by variants in the genes encoding the histone acetyltransferases CBP and p300. In RSTS...

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PMID: 33807238
DOI: 10.3390/ijms22073621
PMCID: PMC8037970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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