Article

Butyrate extends health and lifespan in mice with mitochondrial deficiency

2026-01-14

Abstract excerpt

Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. To investigate novel strategies that alleviate mitochondrial dysfunction, we have generated an ubiquitous and tamoxifen-inducible knockout mouse model of mitochondrial transcription factor A (TFAM), a nuclear-encoded protein involved in mitochondrial DNA (mtDNA) maintenance — Tfam fl/fl Ub Cre-ER...

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Literature Corpus work: d704a888-f0af-5139-9899-5ad648c9c41e
DOI: 10.64898/2026.01.13.699287

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