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Mesodermal-specific <i>MECP2</i> expression in <i>Drosophila</i> induces visceral and skeletal muscle defects rescued by butyrate supplementation

2025-12-18

Abstract excerpt

<h4>Background</h4> Patients affected by Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) experience disabling muscle weakness and gastrointestinal dysmotility of unclear origin. Whether these defects arise cell-autonomously, rather than secondarily to neural dysfunction, and which developmental windows are most vulnerable to MeCP2 disfunction remains unresolved. MeCP2 is a dosage-sensitive transcriptiona...

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Literature Corpus work
84e856b3-2030-5518-9b0c-ac3bc8cb08b1
DOI
10.64898/2025.12.16.694631
Open publication

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Mesodermal-specific <i>MECP2</i> expression in <i>Drosophila</i> induces visceral and skeletal muscle defects rescued by butyrate supplementationDOI 10.64898/2025.12.16.694631
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