Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

doi:10.1161/CIRCGEN.121.003219

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Article

Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

Circulation. Genomic and precision medicine - 1 Apr 2021

Rhainds David, Packard Chris J, Brodeur Mathieu R, Niesor Eric J, Sacks Frank M, Jukema J Wouter, Wright R Scott, Waters David D, Heinonen Therese, Black Donald M, Laghrissi-Thode Fouzia, Dubé Marie-Pierre, Pfeffer Marc A, Tardif Jean-Claude

Abstract excerpt

Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (ADCY9) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in subjects taking dalcetrapib, a CETP (cholesterol ester transfer protein) modulator. Homozygotes for the minor A allele (AA) were protected from recurrent cardiovascular...

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PMID: 33794646
DOI: 10.1161/CIRCGEN.121.003219
PMCID: PMC8284386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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