A sex-specific evolutionary interaction between ADCY9 and CETP.

doi:10.7554/eLife.69198

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A sex-specific evolutionary interaction between ADCY9 and CETP.

eLife - 5 Oct 2021

Gamache Isabel, Legault Marc-André, Grenier Jean-Christophe, Sanchez Rocio, Rhéaume Eric, Asgari Samira, Barhdadi Amina, Zada Yassamin Feroz, Trochet Holly, Luo Yang, Lecca Leonid, Murray Megan, Raychaudhuri Soumya, Tardif Jean-Claude, Dubé Marie-Pierre, Hussin Julie

Abstract excerpt

Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction is still unknown. Here, we characterized selective signals at the locus associated with the pharmacogenomic response in human populations and we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amides

Share to Anticholesteremic Agents

Share to Biological Evolution

Share to Cholesterol Ester Transfer Proteins

Share to Esters

Share to Sex Factors

Share to Sulfhydryl Compounds

Source

Open in PubMed Open full text

Identifiers

PMID: 34609279
DOI: 10.7554/eLife.69198
PMCID: PMC8594919

Genes

CETP
ADCY9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A sex-specific evolutionary interaction between ADCY9 and CETP.PMID 34609279Read ↗

A sex-specific evolutionary interaction between ADCY9 and CETPSemantic proximity Read ↗

Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.Semantic proximity Read ↗

CETP alternative splicing variation impacts human traitsSemantic proximity Read ↗

Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.Semantic proximity Read ↗

ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.Semantic proximity Read ↗

CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?Semantic proximity Read ↗

CETP: Pharmacogenomics-Based Response to the CETP Inhibitor Dalcetrapib.Semantic proximity Read ↗

Advancing Beyond Failed High-density Lipoprotein Clinical Trials to Pharmacogenetic Studies of ADCY9 and Cholesterol Ester Transfer Protein Inhibition.Semantic proximity Read ↗

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.Semantic proximity Read ↗

Study of effect modifiers of genetically predicted CETP reductionSemantic proximity Read ↗

Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children.Semantic proximity Read ↗

Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance With Clinical Outcomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.