Article
CETP: Pharmacogenomics-Based Response to the CETP Inhibitor Dalcetrapib.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017
Tardif Jean-Claude, Rhainds David, Rhéaume Eric, Dubé Marie-Pierre
Abstract excerpt
High-density lipoproteins are involved in reverse cholesterol transport and possess anti-inflammatory and antioxidative properties. Paradoxically, CETP (cholesteryl ester transfer protein) inhibitors have been shown to increase inflammation as revealed by a raised plasma level of high-sensitivity C-reactive protein. CETP inhibitors did not improve clinical outcomes in large-scale clinical trials of unselected...
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