ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.

doi:10.1001/jamacardio.2018.0569

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Article

ADCY9 Genetic Variants and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.

JAMA cardiology - 1 May 2018

Nissen Steven E, Pillai Sreekumar G, Nicholls Stephen J, Wolski Kathy, Riesmeyer Jeffrey S, Weerakkody Govinda J, Foster Wendra M, McErlean Ellen, Li Lin, Bhatnagar Pallav, Ruotolo Giacomo, Lincoff A Michael

Abstract excerpt

Importance: A pharmacogenetic analysis of dalcetrapib, a cholesteryl ester transfer protein inhibitor, reported an association between a single-nucleotide polymorphism (SNP) in the ADCY9 gene (rs1967309) and reduction in major adverse cardiovascular events despite a neutral result for the overall trial. Objective: To determine whether the association between the SNP in the ADCY9 gene and a reduction in major...

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PMID: 29525816
DOI: 10.1001/jamacardio.2018.0569
PMCID: PMC5875353

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ADCY9

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