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Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy

27 Jun 2022

Abstract excerpt

The adenylate cyclase (ADCY) superfamily is a group of glycoproteins regulating intracellular signaling. ADCYs act as key regulators in the cyclic adenosine monophosphate (cAMP) signaling pathway and are related to cell sensitivity to chemotherapy and ionizing radiation. Many members of the superfamily are detectable in most chemoresistance cases despite the complexity and unknownness of the specific mechanism...

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PMID: 35832555
DOI: 10.3389/fonc.2022.829212

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