Article

CETP inhibition and <i>ADCY9</i> genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?

2018-06-06

Abstract excerpt

<h4>Background</h4> CETP inhibitors raise circulating concentrations of HDL-cholesterol, and potent inhibitors also lower non-HDL-cholesterol and risk of vascular disease. Previous genome-wide pharmacogenetic analysis of a phase III randomized controlled trial (RCT) of the CETP inhibitor, dalcetrapib, found variants in ADCY9 to associate with response to treatment. More recently, findings from a pharmacogenetic...

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Literature Corpus work: 821718f4-3fb2-572c-a229-0fe3d4eed3b6
DOI: 10.1101/336875

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