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Article

Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance With Clinical Outcomes.

Circulation. Cardiovascular genetics - 1 Aug 2016

Tardif Jean-Claude, Rhainds David, Brodeur Mathieu, Feroz Zada Yassamin, Fouodjio René, Provost Sylvie, Boulé Marie, Alem Sonia, Grégoire Jean C, L'Allier Philippe L, Ibrahim Reda, Guertin Marie-Claude, Mongrain Ian, Olsson Anders G, Schwartz Gregory G, Rhéaume Eric, Dubé Marie-Pierre

Abstract excerpt

BACKGROUND: Dalcetrapib effects on cardiovascular outcomes are determined by adenylate cyclase 9 gene polymorphisms. Our aim was to determine whether these clinical end point results are also associated with changes in reverse cholesterol transport and inflammation. METHODS AND RESULTS: Participants of the dal-OUTCOMES and dal-PLAQUE-2 trials were randomly assigned to receive dalcetrapib or placebo in addition to...

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Identifiers

PMID: 27418594
DOI: 10.1161/CIRCGENETICS.116.001405
PMCID: PMC4982759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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