Article
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.
Clinical science (London, England : 1979) - 16 Apr 2021
Sun Xiaoguang, Sun Belinda L, Sammani Saad, Bermudez Tadeo, Dudek Steven M, Camp Sara M, Garcia Joe G N
Abstract excerpt
RATIONALE: The myosin light chain kinase gene, MYLK, encodes three proteins via unique promoters, including the non-muscle isoform of myosin light chain kinase (nmMLCK), a cytoskeletal protein centrally involved in regulation of vascular integrity. As MYLK coding SNPs are associated with severe inflammatory disorders (asthma, acute respiratory distress syndrome (ARDS)), we explored clinically relevant...
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