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Article

Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

PloS one - 1 Jan 2015

Shen Kui, Ramirez Benjamin, Mapes Brandon, Shen Grace R, Gokhale Vijay, Brown Mary E, Santarsiero Bernard, Ishii Yoshitaka, Dudek Steven M, Wang Ting, Garcia Joe G N

Abstract excerpt

The MYLK gene encodes the multifunctional enzyme, myosin light chain kinase (MLCK), involved in isoform-specific non-muscle and smooth muscle contraction and regulation of vascular permeability during inflammation. Three MYLK SNPs (P21H, S147P, V261A) alter the N-terminal amino acid sequence of the non-muscle isoform of MLCK (nmMLCK) and are highly associated with susceptibility to acute lung injury (ALI) and...

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Identifiers

PMID: 26111161
DOI: 10.1371/journal.pone.0130515
PMCID: PMC4482139

Genes

MYLK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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