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Article

An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2012

Han Yoo Jeong, Ma Shwu-Fan, Wade Michael S, Flores Carlos, Garcia Joe G N

Abstract excerpt

Intronic single-nucleotide polymorphisms (SNPs) are commonly associated with complex diseases but exhibit unknown biologic functionality. Myosin light-chain kinase (MLCK), a central cytoskeletal regulator encoded by MYLK, plays a key pathophysiological role in complex diseases including acute lung injury (ALI) and asthma. We studied the potential regulatory roles of two intronic MYLK SNPs (rs936170 and rs820336)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Acute Lung Injury
Share to Calcium-Binding Proteins
Share to Electrophoretic Mobility Shift Assay
Share to Enhancer Elements, Genetic
Share to Forkhead Transcription Factors
Share to Lung Diseases
Share to Muscle, Smooth
Share to Myosin-Light-Chain Kinase

Source

Identifiers

PMID: 22015949
DOI: 10.1007/s00109-011-0820-9

Genes

MYLK
FOXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.PMID 22015949Read ↗

A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure.Semantic proximity Read ↗

Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.Semantic proximity Read ↗

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Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.Semantic proximity Read ↗

Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.Semantic proximity Read ↗

A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.Semantic proximity Read ↗

MYLK polymorphism associated with blood eosinophil level among asthmatic patients in a Korean population.Semantic proximity Read ↗

Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma.Semantic proximity Read ↗

Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome.Semantic proximity Read ↗

<i>INKILN</i> is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10Semantic proximity Read ↗

Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.Semantic proximity Read ↗

Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans.Semantic proximity Read ↗

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