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Article

A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure.

European journal of human genetics : EJHG - 1 Jun 2015

Wang Ting, Zhou Tong, Saadat Laleh, Garcia Joe G N

Abstract excerpt

Myosin light-chain kinase (MYLK) is a gene known to be significantly associated with severe asthma in African Americans. Here we further examine the molecular function of a single-nucleotide polymorphism (SNP), located in the non-muscle myosin light-chain kinase isoform (nmMLCK), in asthma susceptibility and pathobiology. We identified nmMLCK variant (reference SNP: rs9840993, NM_053025: 721C>T, c.439C>T) with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25271083
DOI: 10.1038/ejhg.2014.201
PMCID: PMC4795064

Genes

MYLK

Variants

rs9840993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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