Article
The NAMPT promoter is regulated by mechanical stress, signal transducer and activator of transcription 5, and acute respiratory distress syndrome-associated genetic variants.
American journal of respiratory cell and molecular biology - 1 Nov 2014
Sun Xiaoguang, Elangovan Venkateswaran Ramamoorthi, Mapes Brandon, Camp Sara M, Sammani Saad, Saadat Laleh, Ceco Ermelinda, Ma Shwu-Fan, Flores Carlos, MacDougall Matthew S, Quijada Hector, Liu Bin, Kempf Carrie L, Wang Ting, Chiang Eddie T, Garcia Joe G N
Abstract excerpt
Increased nicotinamide phosphoribosyltransferase (NAMPT) transcription is mechanistically linked to ventilator-induced inflammatory lung injury (VILI), with VILI severity attenuated by reduced NAMPT bioavailability. The molecular mechanisms of NAMPT promoter regulation in response to excessive mechanical stress remain poorly understood. The objective of this study was to define the contribution of specific...
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