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Article

Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity.

Journal of cellular biochemistry - 1 Feb 2005

Wadgaonkar Raj, Linz-McGillem Laura, Zaiman Ari L, Garcia Joe G N

Abstract excerpt

Tumor necrosis factor (TNFalpha-) generates both apoptotic and survival signals with endothelial cell (EC) survival dependent on nuclear factor kappa-B (NFkappaB) activation, a regulator of anti-apoptotic genes. We previously demonstrated that increased EC contractility, rearrangement of the actin cytoskeleton, and increased myosin light chain (MLC) phosphorylation occurs as a consequence of TNFalpha-induced...

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Identifiers

PMID: 15526279
DOI: 10.1002/jcb.20250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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