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Article

Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.

American journal of respiratory cell and molecular biology - 1 Jan 2017

Mascarenhas Joseph B, Tchourbanov Alex Y, Fan Hanli, Danilov Sergei M, Wang Ting, Garcia Joe G N

Abstract excerpt

The nonmuscle (nm) myosin light-chain kinase isoform (MLCK), encoded by the MYLK gene, is a vital participant in regulating vascular barrier responses to mechanical and inflammatory stimuli. We determined that MYLK is alternatively spliced, yielding functionally distinct nmMLCK splice variants including nmMLCK2, a splice variant highly expressed in vascular endothelial cells (EC) and associated with reduced EC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27529643
DOI: 10.1165/rcmb.2016-0053OC
PMCID: PMC5248959

Genes

MYLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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