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Article

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling

1 Apr 2021

Abstract excerpt

The reactivity of platelets, which play a key role in the pathogenesis of atherothrombosis, is tightly regulated. The integral membrane protein tetherin/bone marrow stromal antigen-2 (BST-2) regulates membrane organization, altering both lipid and protein distribution within the plasma membrane. Because membrane microdomains have an established role in platelet receptor biology, we sought to characterize the...

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PMID: 33792632
DOI: 10.1182/bloodadvances.2020003182

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