Article
In and out: Traffic and dynamics of thrombopoietin receptor.
Journal of cellular and molecular medicine - 1 Oct 2021
Roy Anita, Shrivastva Saurabh, Naseer Saadia
Abstract excerpt
Thrombopoiesis had long been a challenging area of study due to the rarity of megakaryocyte precursors in the bone marrow and the incomplete understanding of its regulatory cytokines. A breakthrough was achieved in the early 1990s with the discovery of the thrombopoietin receptor (TpoR) and its ligand thrombopoietin (TPO). This accelerated research in thrombopoiesis, including the uncovering of the molecular...
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