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Tetraspanin Scaffold Proteins Function as Key Regulators of Hematopoietic Stem Cells

9 Jul 2020

Abstract excerpt

Hematopoietic stem and progenitor cells (HSPCs) are responsible for the development, maintenance, and regeneration of all the blood forming cells in the body, and as such, are critical for a number of patient therapies. For successful HSPC transplantation, stem cells must traffic through the blood and home to the bone marrow (BM) microenvironment or "niche," which is composed of soluble factors, matrix proteins,...

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PMID: 32754593
DOI: 10.3389/fcell.2020.00598

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