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Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK Biobank

20 Aug 2019

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) genotype affects the risk of Alzheimer's disease (AD) with inconclusive evidence on the opportunity to mitigate related adverse effects by lifestyle changes. OBJECTIVE: To examine the individual and interactive associations of APOE and objectively-measured physical activity (PA) and sedentary activity with cognitive decline. METHODS: We used data from middle-aged and older UK...

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PMID: 31450492
DOI: 10.3233/jad-181132

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