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Article

Ten-year longitudinal effects of physical activity and apolipoprotein E ..4 genotype on precuneus atrophy in Japanese older adults.

Archives of gerontology and geriatrics - 1 Jun 2026

Yuki Atsumu, Nishita Yukiko, Nakamura Akinori, Kato Takashi, Tange Chikako, Zhang Shu, Ando Fujiko, Shimokata Hiroshi, Otsuka Rei

Abstract excerpt

BACKGROUND: The apolipoprotein E ε4 (APOE ε4) allele, a major genetic risk factor for Alzheimer's disease, is associated with early atrophy in the precuneus and posterior cingulate cortex. Whether physical activity can mitigate this atrophy in high-risk APOE ε4 carriers remains unclear. This study aimed to determine whether physical activity can reduce such neurodegenerative changes in older adults carrying this...

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Identifiers

PMID: 41791248
DOI: 10.1016/j.archger.2026.106194

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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