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Article

Alzheimer's disease prevention: Apolipoprotein e4 moderates the effect of physical activity on brain beta-amyloid deposition in healthy older adults.

Journal of science and medicine in sport - 1 Jun 2024

Pedrero-Chamizo Raquel, Zhuang Kailin, Juarez Alexis, Janabi Mustafa, Jagust William J, Landau Susan M

Abstract excerpt

OBJECTIVES: To investigate if higher baseline physical activity levels are associated with less β-amyloid burden and whether the ApoE4 genotype moderates this association cross-sectionally and longitudinally. DESIGN: Prospective cohort study. METHODS: 204 cognitively normal older adults (74.5 ± 6.6 years; 26 % ApoE4-carrier) were analyzed. Baseline physical activity was measured using the Minnesota Physical...

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PMID: 38664148
DOI: 10.1016/j.jsams.2024.03.012

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