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Article

Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Fenesi Barbara, Fang Hanna, Kovacevic Ana, Oremus Mark, Raina Parminder, Heisz Jennifer J

Abstract excerpt

Genetics and lifestyle independently determine dementia risk, but the interaction is unclear. We assessed the interactive relationship of apolipoprotein E (APOE) genotype and physical exercise on dementia risk over a 5-year period in 1,646 older adults from the Canadian Study of Health and Aging who were dementia-free at baseline. Physical exercise moderated the relationship between genotype and dementia...

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Identifiers

PMID: 27911292
DOI: 10.3233/JAD-160424

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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