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Article

Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review.

Ageing research reviews - 1 Dec 2020

de Frutos-Lucas Jaisalmer, Frost Natalie, Erickson Kirk I, Serrano Juan M, Maestu Fernando, Laws Simon M, Brown Belinda M

Abstract excerpt

INTRODUCTION: For decades, researchers have tried to understand the moderating effect of APOE ε4 carriage on the relationship between physical activity (PA), brain health and dementia risk. However, this field has produced inconsistent findings. METHOD: We conducted a systematic review of the literature, searching for observational and interventional studies examining the effect of APOE ε4 carriage on the...

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PMID: 32961338
DOI: 10.1016/j.arr.2020.101173

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