Article
Ultraconserved enhancer function does not require perfect sequence conservation.
Nature genetics - 1 Apr 2021
Snetkova Valentina, Ypsilanti Athena R, Akiyama Jennifer A, Mannion Brandon J, Plajzer-Frick Ingrid, Novak Catherine S, Harrington Anne N, Pham Quan T, Kato Momoe, Zhu Yiwen, Godoy Janeth, Meky Eman, Hunter Riana D, Shi Marie, Kvon Evgeny Z, Afzal Veena, Tran Stella, Rubenstein John L R, Visel Axel, Pennacchio Len A, Dickel Diane E
Abstract excerpt
Ultraconserved enhancer sequences show perfect conservation between human and rodent genomes, suggesting that their functions are highly sensitive to mutation. However, current models of enhancer function do not sufficiently explain this extreme evolutionary constraint. We subjected 23 ultraconserved enhancers to different levels of mutagenesis, collectively introducing 1,547 mutations, and examined their...
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