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Article

Deletion of ultraconserved elements yields viable mice.

PLoS biology - 1 Sept 2007

Ahituv Nadav, Zhu Yiwen, Visel Axel, Holt Amy, Afzal Veena, Pennacchio Len A, Rubin Edward M

Abstract excerpt

Ultraconserved elements have been suggested to retain extended perfect sequence identity between the human, mouse, and rat genomes due to essential functional properties. To investigate the necessities of these elements in vivo, we removed four noncoding ultraconserved elements (ranging in length from 222 to 731 base pairs) from the mouse genome. To maximize the likelihood of observing a phenotype, we chose to...

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Identifiers

PMID: 17803355
DOI: 10.1371/journal.pbio.0050234
PMCID: PMC1964772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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