Article
Recently Evolved Enhancers Emerge with High Interindividual Variability and Less Frequently Associate with Disease.
Cell reports - 23 Jun 2020
Castelijns Bas, Baak Mirna L, Geeven Geert, Vermunt Marit W, Wiggers Caroline R M, Timpanaro Ilia S, Kondova Ivanela, de Laat Wouter, Creyghton Menno P
Abstract excerpt
Mutations in non-coding regulatory DNA such as enhancers underlie a wide variety of diseases including developmental disorders and cancer. As enhancers rapidly evolve, understanding their function and configuration in non-human disease models can have important clinical applications. Here, we analyze enhancer configurations in tissues isolated from the common marmoset, a widely used primate model for human...
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