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Article

Ordered and deterministic cancer genome evolution after p53 loss

17 Aug 2022

Abstract excerpt

, the patterns through which heterogenous TP53 (encoding human p53) mutant genomes emerge and influence tumorigenesis remain poorly understood. Here, in a mouse model of pancreatic ductal adenocarcinoma that reports sporadic p53 loss of heterozygosity before cancer onset, we find that malignant properties enabled by p53 inactivation are acquired through a predictable pattern of genome evolution. Single-cell...

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PMID: 35978189
DOI: 10.1038/s41586-022-05082-5

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