Article

Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas

2021-03-09

Abstract excerpt

<h4>SUMMARY</h4> Deconstructing tissue-specific effects of genes and variants on proliferative advantage is critical to understanding cellular transformation and to systematic selection of cancer therapeutics. Dissecting these specificities at scale requires integrated methods for multiplexed genetic screens tracking fitness across time, across human cell types, and in a suitable cellular niche since functional d...

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Literature Corpus work: 22ef0fb4-177d-547f-98fb-2ab9f6c41fba
DOI: 10.1101/2021.03.09.434648

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