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Article

Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.

Clinical pharmacology and therapeutics - 1 Sept 2021

Liu Yiwei, Yang Wenjian, Smith Colton A, Cheng Cheng, Karol Seth E, Larsen Eric C, Winick Naomi, Carroll William L, Loh Mignon L, Raetz Elizabeth A, Hunger Stephen P, Winter Stuart S, Dunsmore Kimberly P, Devidas Meenakshi, Yang Jun J, Evans William E, Jeha Sima, Pui Ching-Hon, Inaba Hiroto, Relling Mary V

Abstract excerpt

We conducted the first human leukocyte antigen (HLA) allele and genome-wide association study to identify loci associated with hypersensitivity reactions exclusively to the PEGylated preparation of asparaginase (pegaspargase) in racially diverse cohorts of pediatric leukemia patients: St Jude Children's Research Hospital's Total XVI (TXVI, n = 598) and Children's Oncology Group AALL0232 (n = 2,472) and AALL0434...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33768542
DOI: 10.1002/cpt.2241
PMCID: PMC8790808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.PMID 33768542Read ↗

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