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Article

Two tagging single-nucleotide polymorphisms to capture HLA-DRB107:01-DQA102:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity.

British journal of clinical pharmacology - 1 Jun 2021

Kutszegi Nóra, Gézsi András, F Semsei Ágnes, Müller Judit, Simon Réka, Kovács Erika Rozália, Hegedüs Katalin, Kovács Gábor T, Szalai Csaba, Erdélyi Dániel J

Abstract excerpt

AIMS: Asparaginase (ASP) hypersensitivity is a well-known challenge in the treatment of lymphoblastic malignancies. In terms of cost considerations, the cheap native Escherichia coli ASP, the most immunogenic form of this medication, is used in the first line in middle-income countries. Previously, the role of the HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype had been established to associate with E. coli ASP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33217039
DOI: 10.1111/bcp.14664
PMCID: PMC8247313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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