Article
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene.
Drug metabolism and personalized therapy - 1 Mar 2017
Lopez-Santillan Maria, Iparraguirre Leire, Martin-Guerrero Idoia, Gutierrez-Camino Angela, Garcia-Orad Africa
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is a major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, hypersensitivity reactions are common. In those cases,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.