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Article

Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.

Oncotarget - 4 Jul 2017

Abaji Rachid, Gagné Vincent, Xu Chang Jiang, Spinella Jean-François, Ceppi Francesco, Laverdière Caroline, Leclerc Jean-Marie, Sallan Stephen E, Neuberg Donna, Kutok Jeffery L, Silverman Lewis B, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

Allergy, pancreatitis and thrombosis are common side-effects of childhood acute lymphoblastic leukemia (ALL) treatment that are associated with the use of asparaginase (ASNase), a key component in most ALL treatment protocols. Starting with predicted functional germline variants obtained through whole-exome sequencing (WES) data of the Quebec childhood ALL cohort we performed exome-wide association studies with...

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Identifiers

PMID: 28574850
DOI: 10.18632/oncotarget.17959
PMCID: PMC5546438

Genes

SPEF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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