HLA-DRB1*16:02 is associated with PEG-asparaginase hypersensitivity.

doi:10.2217/pgs-2021-0107

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Article

HLA-DRB1*16:02 is associated with PEG-asparaginase hypersensitivity.

Pharmacogenomics - 1 Nov 2021

Liu Shuguang, Gao Chao, Wu Ying, Lin Wei, Li Jun, Xue Tianlin, Wang Linya, Zheng Huyong, Zhang Ruidong

Abstract excerpt

Aim: To evaluate the associations between human leukocyte antigen (HLA)-DRB1 variants and the rs6021191 variant in nuclear factor of activated T cells 2 (NFATC2) with PEG-asparaginase hypersensitivity in children with acute lymphoblastic leukemia (ALL) treated according to the Chinese Children Leukemia Group (CCLG) ALL 2018 protocol. Methods:HLA-DRB1 genotyping was performed using a PCR sequence-based typing...

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PMID: 34747637
DOI: 10.2217/pgs-2021-0107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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