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HLA Alleles Associated with Asparaginase Hypersensitivity in Childhood ALL: A Report from the DFCI Consortium

6 May 2020

Abstract excerpt

Aim: To evaluate the association between human leukocyte antigen (HLA) alleles and native Escherichia coli asparaginase hypersensitivity (AH) in children with acute lymphoblastic leukemia (ALL) who received Dana-Farber Cancer Institute treatment protocols. Patients & methods: HLA-DQA1, HLA-DRB1 and HLA-DQB1 alleles were retrieved from available whole exome sequencing data of a subset of childhood ALL patients...

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PMID: 32372697
DOI: 10.2217/pgs-2019-0195

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