Article
Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.
PloS one - 1 Jan 2015
Kutszegi Nóra, Semsei Ágnes F, Gézsi András, Sági Judit C, Nagy Viktória, Csordás Katalin, Jakab Zsuzsanna, Lautner-Csorba Orsolya, Gábor Krisztina Míta, Kovács Gábor T, Erdélyi Dániel J, Szalai Csaba
Abstract excerpt
L-asparaginase (ASP) is a key element in the treatment of paediatric acute lymphoblastic leukaemia (ALL). However, hypersensitivity reactions (HSRs) to ASP are major challenges in paediatric patients. Our aim was to investigate genetic variants that may influence the risk to Escherichia coli-derived ASP hypersensitivity. Sample and clinical data collection was carried out from 576 paediatric ALL patients who were...
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