Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.

doi:10.1080/14622416.2025.2572961

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Article

Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.

Pharmacogenomics - 1 Jan 2025

Cecconello Daiane Keller, de Souza Silva Klerize Anecely, de Senna Evelin Cristine Mendonça, Carlotto Lucas Alfeu, de Souza Amanda Másculo, Lins Mecneide Mendes, Magalhães Isis Maria Quezado Soares, de Sousa Ana Virgínia Lopes, Epelman Sidnei, Cristofani Lilian, Barros Tais Tereziano, Pianovski Mara, Moreira Larissa Polis, Rechenmacher Ciliana, Daudt Liane Esteves, Michalowski Mariana Bohns

Abstract excerpt

AIMS: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Although PEG-asparaginase (PEG-ASNase) is a key drug in treatment, hypersensitivity reactions, pancreatitis, and silent inactivation remain major challenges. Interindividual genetic variability influences drug metabolism and toxicity, and pharmacogenetic research aims to identify these variants early to predict specific responses...

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Identifiers

PMID: 41229266
DOI: 10.1080/14622416.2025.2572961
PMCID: PMC12667641

Genes

ARHGAP28
CNOT3
GRIA1
MYBBP1A
NFATC2
RGS6
ULK2

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Related research

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Research trail→

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Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.PMID 41229266Read ↗

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Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

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