Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus.

doi:10.1136/annrheumdis-2020-219727

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Article

Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Sept 2021

Reid Sarah, Hagberg Niklas, Sandling Johanna K, Alexsson Andrei, Pucholt Pascal, Sjöwall Christopher, Lerang Karoline, Jönsen Andreas, Gunnarsson Iva, Syvänen Ann-Christine, Troldborg Anne Margrethe, Voss Anne, Bengtsson Anders A, Molberg Øyvind, Jacobsen Søren, Svenungsson Elisabet, Rönnblom Lars, Leonard Dag

Abstract excerpt

OBJECTIVE: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. METHODS: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer and activator of...

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PMID: 33766895
DOI: 10.1136/annrheumdis-2020-219727
PMCID: PMC8372395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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