Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production.

doi:10.1002/art.42435

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Article

Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2023

Madera-Salcedo Iris K, Ramírez-Sánchez Ada L, Rodríguez-Rodríguez Noé, García-Quintero Roberto, Rubio Rosa M, Morales-Montes de Oca Gabriela, Dávalos Emmanuel, Cuervo Rogelio, Furuzawa-Carballeda Janette, Alcocer-Varela Jorge, Gómez-Martín Diana, González-Yáñez Marysol, de la Cruz Abigail, Albarrán-Godínez Adrián, Suárez-Rojas Gerardo, Romero-Díaz Juanita, Uribe-Uribe Norma O, Alarcón-Riquelme Marta, Furlan-Magaril Mayra, Mejía-Vilet Juan Manuel, Crispín José C, Rosetti Florencia

Abstract excerpt

OBJECTIVE: Variants in STAT4 are associated with systemic lupus erythematosus (SLE) and other autoimmune diseases. We undertook this study to investigate how disease-associated variants affect STAT4 expression, in particular in CD4+ T cells where STAT4 plays an essential role. METHODS: We compared Th1 differentiation between naive CD4+ T cells from healthy donors homozygous for the risk (R/R) or nonrisk (NR/NR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36575804
DOI: 10.1002/art.42435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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