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Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Dec 2020

Xia Hongjie, Shi Pei-Yong

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved multiple...

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COVID-19
COVID-19 Vaccines
Immune System
Immunity, Innate
Interferon Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Nonstructural Proteins

Virus Replication

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PMID: 33337934
DOI: 10.1089/jir.2020.0214
PMCID: PMC7757701

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