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Article

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

7 Mar 2021

Abstract excerpt

Background The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses share a completely homologous repertoire of proteins and use the same cellular entry receptor, their transmission efficiencies and pathogenetic traits differ. We aimed to compare interferon antagonism by SARS-CoV and SARS-CoV-2. Methods For...

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PMID: 33969329
DOI: 10.1016/s2666-5247(21)00027-6

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