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Article

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries.

Clinical science (London, England : 1979) - 16 Apr 2021

Karle Weronika, Becker Samuel, Stenzel Philipp, Knosalla Christoph, Siegel Günter, Baum Oliver, Zakrzewicz Andreas, Berkholz Janine

Abstract excerpt

Promyelocytic leukemia protein (PML) is a constitutive component of PML nuclear bodies (PML-NBs), which function as stress-regulated SUMOylation factories. Since PML can also act as a regulator of the inflammatory and fibroproliferative responses characteristic of atherosclerosis, we investigated whether PML is implicated in this disease. Immunoblotting, ELISA and immunohistochemistry showed a stronger expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33764440
DOI: 10.1042/CS20201399

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