Article
Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2006
Hao Hiroyuki, Gabbiani Giulio, Camenzind Edoardo, Bacchetta Marc, Virmani Renu, Bochaton-Piallat Marie-Luce
Abstract excerpt
OBJECTIVE: Characterize the phenotypic features of media and intima coronary artery smooth muscle cells (SMCs) in mildly stenotic plaques, erosions, stable plaques, and in-stent restenosis. METHODS AND RESULTS: Expression of alpha-smooth muscle actin (alpha-SMA), smooth muscle myosin heavy chains (SMMHCs), and smoothelin was investigated by immunohistochemistry followed by morphometric quantification. The...
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