Article
Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism.
NeuroImage - 15 Apr 2014
Forde Natalie J, Ronan Lisa, Suckling John, Scanlon Cathy, Neary Simon, Holleran Laurena, Leemans Alexander, Tait Roger, Rua Catarina, Fletcher Paul C, Jeurissen Ben, Dodds Chris M, Miller Sam R, Bullmore Edward T, McDonald Colm, Nathan Pradeep J, Cannon Dara M
Abstract excerpt
BACKGROUND: The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition. Although a met-dose effect is generally assumed, to date the paucity of met-homozygotes have limited our understanding of the role of the met-allele on brain structure. METHODS: To investigate this phenomenon, we...
Topics
- Adolescent
- Adult
- Alleles
- Brain
- Brain-Derived Neurotrophic Factor
- Diffusion Tensor Imaging
- Female
- Genotype
- Heterozygote
- Homozygote