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Article

Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.

Cell reports - 23 Mar 2021

Han Yongchao, Zhuang Na, Wang Tao

Abstract excerpt

The maintenance of mitochondrial homeostasis requires PTEN-induced kinase 1 (PINK1)-dependent mitophagy, and mutations in PINK1 are associated with Parkinson's disease (PD). PINK1 is also downregulated in tumor cells with PTEN mutations. However, there is limited information concerning the role of PINK1 in tissue growth and tumorigenesis. Here, we show that the loss of pink1 caused multiple growth defects...

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Identifiers

PMID: 33761355
DOI: 10.1016/j.celrep.2021.108875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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