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Article

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

15 Nov 2021

Abstract excerpt

Myofiber atrophy occurs with aging and in many diseases but the underlying mechanisms are incompletely understood. Here, we have used >1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the developmental growth of body wall skeletal muscles in Drosophila. This screen identifies new regulators of myofiber atrophy and hypertrophy, including the...

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PMID: 34780463
DOI: 10.1371/journal.pgen.1009926

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